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Serum No. 21Crow's Feet + Fine Lines

  • Overview

    Serum No. 21 is an exclusive formula designed to minimize the appearance of crow's feet and fine lines around the eyes by promoting skin regeneration and maximizing hydration. Each coconut-derived biocellulose eye mask is generously infused with our proprietary serum formulation, which is clinically proven to accelerate the skin's natural healing process for a smoother, tighter, and more luminous appearance. The accompanying serum roller optimizes results when used between mask treatments.

    Skin Conditions

    Serum No. 21 reduces the appearance of crow's feet, fine lines, and other wrinkles around the eyes caused by sun damage, aging, and repetitive movements.

  • NuvesseMD is committed to formulating our serums from natural, scientifically proven ingredients. Learn more about our ingredients.

    Active Ingredients


    Antixodiants: The antioxidant ingredients found in Serum No. 21 reduce the effects of past environmental damage while fortifying skin against future harm.

    Ascorbyl Palmitate (Vitamin C)

    Ascorbyl Palmitate (Vitamin C): This antioxidant kick-starts collagen growth and neutralizes free radicals, nourishing skin and improving its elasticity and firmness.


    Glycerin: This powerful humectant deeply hydrates by drawing in moisture from the air. Glycerin reduces inflammation and is friendly to sensitive skin.

    Retinyl Palmitate (Vitamin A)

    Retinyl Palmitate (Vitamin A): A form of retinol, this vitamin A derivative helps boost collagen synthesis and speed elastin production.

    Complete Ingredients

    Injectable grade water, 2-propanol, hyaluronic acid, acetyl hexapeptide-8, glycerin, aloe vera oil, caffeine, retinyl palmitate (Vitamin A), tocopheryl acetate (Vitamin E), ascorbyl palmitate (Vitamin C), copper peptide, polyhexamethylene biguanide hydrochloride, lavender oil

  • Step 1

    After washing your face, open pouch, remove tray and select right or left eye mask from tray. Remove one of the two blue liners.

    Step 2

    Begin by applying the wider end of the mask underneath the eye, smoothing to the outside corner, covering the crow’s feet area. The remaining blue liner should face out. Once fitted, press it firmly against your skin. Apply the second eye mask in similar fashion.

    Step 3

    After 5 minutes, the mask will begin to mold to your face. Using the tab near the forehead, peel off the remaining blue liner. Gently press the mask so that it attaches evenly to your face.

    Step 4

    When the serum is absorbed (approx. 45 minutes), remove the mask and gently pat your face with your palms and fingertips, enabling your skin to absorb any excess.

    Usage: For maximum benefit, please wear your eye mask for 45 minutes twice a week so all of the active ingredients have time to penetrate deeply into the skin. However, if you only have 20-30 minutes, you will still notice a wonderful change to your skin.

  • Apply the roller serum directly to skin around the eye area and pat to absorb excess as necessary. Apply morning and night after cleansing and on the go as desired.

    Avoid any contact directly with the eye and eyelid.

  • Serum No. 21 Kit


    Four 10mL eye mask sets, One 10mL roller vial

  • Serum No. 21 Roller


    One 10mL roller vial

Serum No. 21


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